Publications George Posthuma

20 selected

 

Elgersma RC, Posthuma G, Rijkers DT, Liskamp RM. Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials. J Pept Sci. 2007 Nov;13(11):709-16.

 

Hendrickx AP, van Wamel WJ, Posthuma G, Bonten MJ, Willems RJ. Five Genes Encoding Surface-Exposed LPXTG Proteins Are Enriched in Hospital-Adapted Enterococcus faecium Clonal Complex 17 Isolates. J Bacteriol. 2007 Nov;189(22):8321-32. Epub 2007 Sep 14.

 

van Donselaar E, Posthuma G, Zeuschner D, Humbel BM, Slot JW. Immunogold labeling of cryosections from high-pressure frozen cells. Traffic. 2007 May;8(5):471-85.

 

Elgersma RC, Mulder GE, Kruijtzer JA, Posthuma G, Rijkers DT, Liskamp RM. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1837-42. Epub 2007 Jan 24.

 

Van Wamel WJ, Hendrickx AP, Bonten MJ, Top J, Posthuma G, Willems RJ. Growth condition-dependent Esp expression by Enterococcus faecium affects initial adherence and biofilm formation. Infect Immun. 2007 Feb;75(2):924-31. Epub 2006 Nov 21.

 

Elgersma RC, Meijneke T, de Jong R, Brouwer AJ, Posthuma G, Rijkers DT, Liskamp RM. Synthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials. Org Biomol Chem. 2006 Oct 7;4(19):3587-97. Epub 2006 Aug 21.

 

Elgersma RC, Meijneke T, Posthuma G, Rijkers DT, Liskamp RM. Self-assembly of amylin(20-29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils. Chemistry. 2006 May 3;12(14):3714-25.

 

Kranenburg O, Bouma B, Gent YY, Aarsman CJ, Kayed R, Posthuma G, Schiks B, Voest EE, Gebbink MF. Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation. Mol Cell Neurosci. 2005 Mar;28(3):496-508.

 

Bouwman J, Maia AS, Camoletto PG, Posthuma G, Roubos EW, Oorschot VM, Klumperman J, Verhage M. Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience. 2004;126(1):115-26.

 

Murk J.L., G. Posthuma, A.J. Koster, H.J. Geuze, A.J. Verkleij, M.J. Kleijmeer , B.M. Humbel . 2003. Influence of aldehyde fixation on the morphology of endosomes and lysosomes: quantitative analysis and electron tomography. J Microsc. 212:81-90.

 

ten Brinke A, G. Posthuma, J.J. Batenburg, H.P. Haagsman, A.N.Ridder, L.M. van Golde, A.B. Vaandrager. 2003. The transmembrane domain of surfactant protein C precursor determines the morphology of the induced membrane compartment in CHO cells. Eur J Cell Biol. 82:285-294.

 

Griffith, J.M., and G. Posthuma. 2002. A reliable and convenient method to store ultrathin thawed cryosections prior to immunolabeling. J Histochem Cytochem. 50:57-62.

 

Rijkers, D.T., J.W. Hoppener, G. Posthuma, C.J. Lips, and R.M. Liskamp. 2002. Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and alpha-hydroxy acid residue containing peptides. Chemistry. 8:4285-4291.

 

Oprins, A., C. Rabouille, G. Posthuma, J. Klumperman, H.J. Geuze, and J.W. Slot. 2001. The ER to Golgi interface is the major concentration site of secretory proteins in the exocrine pancreatic cell. Traffic. 2:831-838.

 

Van de Weert, M., R. van 't Hof, J. van der Weerd, R.M. Heeren, G. Posthuma, W.E. Hennink, and D.J. Crommelin. 2000. Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques. J Control Release. 68:31-40.

 

Hoppener, J.W., C. Oosterwijk, M.G. Nieuwenhuis, G. Posthuma, J.H. Thijssen, T.M. Vroom, B. Ahren, and C.J. Lips. 1999. Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model. Diabetologia. 42:427-434.

 

Neeleman, C., S.P. Geelen, P.C. Aerts, M.R. Daha, T.E. Mollnes, J.J. Roord, G. Posthuma, H. van Dijk, and A. Fleer. 1999. Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H. Infect Immun. 67:4517-4524.

 

Rijnboutt, S., G. Jansen, G. Posthuma, J.B. Hynes, J.H. Schornagel, and G.J. Strous. 1996. Endocytosis of GPI-linked membrane folate receptor-alpha. J Cell Biol. 132:35-47.

 

Slot, J.W., G. Posthuma, L.Y. Chang, J.D. Crapo, and H.J. Geuze. 1989. Quantitative aspects of immunogold labeling in embedded and in nonembedded sections. Am J Anat. 185:271-281.

 

Posthuma, G., J.W. Slot, T. Veenendaal, and H.J. Geuze. 1988. Immunogold determination of amylase concentrations in pancreatic subcellular compartments. Eur J Cell Biol. 46:327-335.